8D: Granular & Macroporous Biomaterials for Tissue Engineering 2
Time: 10:30 AM to 12:30 PM
Description
Granular hydrogel materials emerged as a class of biomaterial that provide for well-defined in vitro and in vivo systems with plug-and-play components and tissue-mimicking 3D environments. Granular hydrogels are composed of a slurry of microgel particles that are assembled to form a larger porous structure. Microporous annealed particle (MAP) scaffolds are a subclass of granular hydrogel material with a void space network stabilized by inter-particle chemical bonds. The modular nature of granular hydrogels offers enormous tunability in not only the individual microgel design but also the homogenous or heterogenous microgel assembly into the bulk scaffold. This session will explore current advances in granular hydrogel technology, including MAP scaffolds, for both immune modulation, tissue repair, organ-on-a-chip, and 3D-printing applications
Moderators:
Donald Griffin, University of Virginia
Tatiana Segura, Duke University
Objectives
10:30 AM. 394. MAP scaffolds modulate collagen fibril formation and fibroblast phenotype.Alejandra Suarez Arnedo1, Michaela Harris1, Ari Willig1, Brenton D Hoffman1, Tatiana Segura, PhD1 1Duke University
11:00 AM. 395. A Novel PEG-Based Injectable Macroporous Hydrogel Scaffold.Mary Dickenson, MSE1, Sydney Wheeler, MSE1, Kiera Downey, MSE1, Weiping Li, PhD1, Jan Stegemann, PhD1, Cheri Deng, PhD1, Aaron Morris, PhD1 1University of Michigan
10:45 AM. 396. Investigating the Impact of Biomaterial Chirality on Host-material Interaction Using a Limited Lymphocyte Egress Model.Eleanor L.P. Caston1, Yongjae Lee1, Pablo Cordero Alvarado1, Michelle Schneider, MD/PhD1, Tatiana Segura, PhD1 1Duke University
11:15 AM. 397. Alginate granular scaffolds support formation of hypertrophic and chondrogenic constructs made from ECM-loaded MSC spheroids.David H Ramos-Rodriguez1, Andrea C Filler1, J. Kent Leach1 1UC Davis Health
11:30 AM. 398. Development of Avidity-Controlled Biotherapeutic Delivery Systems for the Treatment of Acute Kidney Injury.Arielle D'Elia, MS1, Kenneth Kim, MS2, Carl Russell III, BS3, Akari Seiner, MS1, Alex Osidach, M.S.1, Winni Gao, BS1, Danielle Soranno, MD3, Christopher Rodell, Ph.D.1 1Drexel University, 2Drexel University College of Medicine, 3Indiana University
11:45 AM. 399. Granular Hydrogel Composites for Microvascularized Engineered Tissue Grafts.Michael Hu, MS1, Gonzalo Anyosa-Galvez1, Firaol Midekssa, MS1, Brendon Baker, Ph.D.1 1University of Michigan
Santiago Orrego, Temple University
12:00 PM. 400. Multicellular Granular Hydrogels of the Perivascular Niche to Study Glioblastoma Progression.Brittany Payan, B.S.1, Tejasvi Anand, B.S.1, Joel Kattoor1, Brendan Harley, ScD1 1University of Illinois Urbana-Champaign
12:15 PM. 401. Programmed Shape Transformations in Cell-laden Granular Hydrogel Composites.Nikolas Di Caprio1, Alex Hughes, PhD2, Jason Burdick3 1University of Pennslyvania, 2University of Pennsylvania, 3University of Colorado, Boulder