6D: Extracellular Vesicles for Biomedical Applications
Time: 1:30 PM to 3:30 PM
Description
Extracellular vesicles (EVs) are natural nanoparticles that carry RNA, DNA, proteins, and lipids, and have been given much attention in recent years due to the growing knowledge of their role in driving disease and maintaining health. The objective of this session is to bring together investigators focusing on the characterization and biology of EVs, engineering of EVs, and their utility as diagnostic biomarkers and therapeutics. Example topics include EV nanomaterials science, the interaction of EVs with biological systems, EV biodistribution in vivo and pharmacology, and the utility of EVs for molecular targeting, imaging, diagnostics, immunoengineering, tissue engineering, and drug delivery. EVs from different sources including both mammalian and bacteria-derived EVs will be included.
Moderator:
Eun Ji Chung, University of Southern California
Objectives
1:30 PM. 268. Silicon nanowires augment therapeutic extracellular vesicle production from human cardiac organoids.Ryan Barrs, PhD1, Nathaniel Hyams, BS2, Mei Li, MD1, Bozhi Tian, PhD3, Ying Mei, PhD2 1Medical University of South Carolina, 2Clemson University, 3University of Chicago
1:45 PM. 269. Piezoelectric nanofibrous scaffold (PES) as a 3D culture platform for enhancing the production of small extracellular vesicles.James Johnston1, Hyunsu Jeon1, Yun Young Choi1, Gaeun Kim1, Tiger Shi1, Courtney Khong1, Hsueh-Chia Chang1, Nosang Myung1, Yichun Wang1 1University of Notre Dame
2:00 PM. 270. Engineered Biomimetic Materials for Enhancing Therapeutic Small Extracellular Vesicles.Yichun Wang1 1University of Notre Dame
2:15 PM. 271. Extracellular Vesicle-incorporated Biostimulatory Matrix Prevents Radiation Dermatitis.Jiayuan Kong1, Kedar Krishnan1, Hexiang Feng1, Kailei Ding1, Sashank Reddy, MD, Ph.D1, Hai-Quan Mao, Ph.D.1 1Johns Hopkins University
2:30 PM. 272. Chiral-Assisted siRNA Loading and pH-Responsive Peptide Functionalization in Small Extracellular Vesicles for Efficient Intracellular Delivery.Gaeun Kim1, Runyao Zhu1, Sihan Yu, PhD1, Bowen Fan1, Jennifer Leon1, Matthew Webber, PhD1, Yichun Wang1 1University of Notre Dame
2:45 PM. 273. Urinary extracellular vesicles as gene and protein delivery devices.
3:00 PM. 274. Engineering Lipid Nanoparticles as a Delivery Vehicle for Novel Extracellular Vesicle-Derived Therapeutics.Lauren Hawthorne1, George Ronan1, Dila Bozkaya1, Jun Yang1, Pinar Zorlutuna1 1University of Notre Dame
3:15 PM. 275. Bioengineering Customized Exosomes as a Cell-free Therapy for Volumetric Muscle Loss Injuries.Breanne Welsh1, Surendrasingh Y Sonaye1, Prabaha Sikder, PhD1 1Cleveland State University