6C: Biomaterial-Based Cancer Models

Date: Friday, April 11, 2025
Time: 1:30 PM to 3:30 PM
Room: BLVD B
Session Type: General Session

Description

Biomaterial-based cancer models offer a close mimic of the complex tumor microenvironment, providing versatile platforms for screening molecular and cellular therapeutics. Such platforms enable integration of multiple cell populations and matrix compositions, treatment with patient-relevant modalities (e.g. radiation therapies), and detailed mechanistic analysis through high-resolution imaging. This symposium will highlight recent advances in leveraging biomaterial-based cancer models in vitro or in vivo, to accelerate therapeutic delivery with high efficacy and low associated toxicity.

Moderators:

Ricardo Cruz-Acuna, Columbia University
Sara Pedron-Haba, University of Illinois Urbana-Champaign
Silviya Zustiak, Saint Louis University

Objectives

  • 2:00 PM. 262. Biomaterial-based modeling of radiotherapy outcomes impacts tumor-stroma interactions.Isabella Rivera1, Ryan Yao1, Kimberly Selting, DVM1, Catherine Best-Popescu, PhD1, Brendan Harley, ScD1, Sara Pedron-Haba, PhD1 1University of Illinois Urbana-Champaign

  • 2:15 PM. 263. Microgel Encapsulation of Glioblastoma for an In Vitro Drug Screening Platform.Brittany Payan, B.S.1, Annika Carrillo diaz de leon1, Tejasvi Anand, B.S.1, Gunnar Thompson, B.S.1, Brendan Harley, ScD1 1University of Illinois Urbana-Champaign

  • 2:30 PM. 264. Engineering Dormancy: Insights from a 3D Model of Microscopic Colorectal Cancer Liver Metastasis.Sabrina VandenHeuvel1, Sanjana Roy1, Brinlee Goggans1, Oscar Benavides, PhD1, Alex Walsh, PhD1, Scott Kopetz, MD, PhD2, Shreya Raghavn, PhD1 1Texas A&M University, 2MD Anderson Cancer Center

  • 2:45 PM. 265. A spatially patterned 3D model for assessing drug efficacy in breast cancer-bone metastasis.Vedant Chittake1, Michelle Tai, BS2, Fan Yang, Ph.D.2 1Fan Yang Lab, Stanford University, 2Stanford University

  • 3:00 PM. 266. Embedded Bioprinting of Breast Cancer–Adipose Composite Tissue Model for Patient-Specific Paracrine Interaction Analysis.Wonwoo Jeong, PhD1 1Wake Forest Institute for Regenerative Medicine

  • 3:15 PM. 267. Extracellular matrix cues combine to generate diverse phenotypes during breast cancer progression.Ryan Stowers, Ph.D.1, Abhishek Sharma1, Rowan Steger1, Siddharth Dey, Ph.D.1, Kellie Heom1 1UC Santa Barbara

Speakers