6B: Advancing the Hemocompatibility of Biomaterials
Time: 1:30 PM to 3:30 PM
Description
Biomaterial surfaces routinely initiate blood coagulation, creating a grand challenge to the development of blood-contacting technologies and the clinical use of cardiovascular devices. Surface designs based on passivation, presentation of bioactive components, or controlled release of anticoagulant and antiplatelet agents are of interest for improving the hemocompatibility of vascular devices for short-term, long-term, and dynamic blood-contacting applications. This symposium will cover the development of new biomaterial design strategies for preventing thrombosis, methods of surface-directed control of cell-surface interactions in the vascular context, in vitro and preclinical models of thrombosis in biomaterials evaluation, as well as fundamental studies of blood-biomaterial interactions.
Moderators:
Hitesh Handa, University of Georgia
Mark Garren, University of Georgia
Objectives
1:30 PM. 253. In Vitro and In Vivo Assessment of Fluorinated Polyphosphazene Catheter Coatings.Bryan Gregorits1, Yi Wu2, Hitesh Handa2, Chen Chen1, Harry Allcock1, Eric Yeager3, Christopher Siedlecki3, Lichong Xu3 1Penn State University, 2University of Georgia, 3Penn State College of Medicine
1:45 PM. 254. Carboxymethyl kappa-carrageenan: anticoagulant coatings as sustainable alternatives to heparin for blood contacting devices.Liszt Yeltsin Madruga1, Ketul Popat1, Matt J Kipper2, Roberta Sabino3, Somayeh Baghersad2 1George Mason University, 2Colorado State University, 3University of Wyoming
2:00 PM. 255. Cytocompatible and Hemocompatible, Slippery Organogel Coatings Integrated with Bioactive Polymers.Isabel Martinez1, Arpita Shome, PhD1, Myddelton parker2, Yi Wu1 1University of Georgia, 2Universiry of Georgia
2:15 PM. 256. Liquid-Infused (LI) Nitric Oxide (NO) Releasing Submicron-Textured Surfaces for Biocompatibility in Biomedical Devices.Gaurav Pandey1, Asma Khursheed2, Li-Chong Xu, PhD2, Christopher Siedlecki1 1Penn state college of Medicine, 2Pennsylvania State University College of Medicine
2:30 PM. 257. New thermoplastic elastomers for safer, greener and customizable blood-contacting medical devices with antithrombotic profile.Sofia F. Melo1, Anna Pierrard1, Christophe Detrembleur1, Christine Jerome1, Patrizio Lancellotti1, Cecile Oury1 1University of Liege
2:45 PM. 258. Dual surface functionalization of microfluidic blood oxygenators using antithrombin-heparin (ATH) and tissue plasminogen activator (t-PA) for enhanced antithrombotic activity.Siyuan Li1, Neda Saraei1, Helen Atkinson1, Christoph Fusch2, Niels Rochow2, Gerhard Gerhard1, Ravi Selvaganapathy1, John Brash1, Anthony Chan1, Kyla Sask1 1McMaster University, 2University Hospital Nuremberg
3:00 PM. 259. Bioinspired Endothelium-Mimicking Slippery Surface: Long-Term In Vivo Infectious Rabbit Model.Yi Wu1, Patrick Maffe1, Mark Garren1, Aasma Sapkota1, Grace Nguyen1, keren Beita1, Chad Schmiedt, DVM, DACVS1, Elizabeth J. Brisbois1, Hitesh Handa1 1University of Georgia
3:15 PM. 260. Improving the Thromboresistivity of Devices via Surface-Localized Release of Hydrogen Sulfide.Mark Garren1, Rashmi Pandey, PhD1, Morgan Ashcraft, PhD1, Yi Wu1, Dagney Crowley, N/A1, Elizabeth J. Brisbois1, Hitesh Handa1 1University of Georgia