5G: Nanomedicine for Targeted Drug Delivery 1
Time: 8:00 AM to 10:00 AM
Description
This session will emphasize product development and translational nanomedicine, including but not limited to evaluation of product effectiveness in vivo in disease models, nanomedicine manufacturing, and nanomedicine quality control for specific applications. Nanomedicines include colloids and other nanomaterials that have been engineered to target delivery of diverse payloads (such as small molecules, nucleic acids, or biologics) to specific cells or tissues. Targeting approaches may include but are not restricted to cell membrane coating, surface modification, engineering of particle geometry, or engineering other biophysical parameters. Abstracts from academic researchers with translational products or devices are welcomed and abstracts from industry members are especially encouraged.
Moderators:
Gopal Agarwal, University of Florida
Xiao Huang, Drexel University
Marissa Wechsler, University of Texas at San Antonio
Objectives
9:00 AM. 229. Dual-targeting of uPAR and Ribonucleotide Reductase R2 in Triple-Negative Breast Cancer and Stromal Cells for Better Tumor Retention and Enhanced Therapeutic Efficacy.Hsin-Yin Chuang1, Da Huang2, Vidit Singh1, Lin Qi1, Anna Chernatynskaya1, Yue-Wern Huang1, Hu Yang1 1Missouri University of Science and Technology, 2Fuzhou University
8:00 AM. 230. Ligand-targeted polymeric mRNA nanoparticles exhibit T cell tropism for in vivo CAR T cell engineering.Manav Jain1, Savannah Est-Witte1, Sydney Shannon1, Francis Yu1, Jonathan Schneck1, Stephany Tzeng1, Jordan Green, Ph.D.1 1Johns Hopkins University
8:15 AM. 231. Engineering protein-conjugated lipid nanoparticles for targeted, extrahepatic mRNA delivery to the placenta.Hannah Geisler, MS1, Hannah Safford1, Ajay Thatte, MS1, Michael Mitchell, Ph.D.1 1University of Pennsylvania
8:30 AM. 232. Protein Corona Impacts Targeting and Affinity of Layer-by-Layer Nanoparticles.Simone Douglas-Green1, Tamara Dacoba Gomez2, Bhuvna Murthy2, Alfonso Restrepo2, N. Daniel Hills1, Paula Hammond2 1Georgia Tech and Emory University, 2MIT
8:45 AM. 233. Pemetrexed as folate receptor-α (FRα) targeting moiety, active targeting of colorectal cancer using chemotherapy-loaded nanoparticles..Mohammad Alnatour1, Ramkrishna Sen1, Lokesh Janardhanam1, Sean Geary, PhD1, Aliasger Salem, PhD1 1University of Iowa
9:15 AM. 234. In vitro and in vivo development of rat macrophage membrane coated nanoparticles for targeted delivery to inflamed peripheral nerves.Chanpreet Kaur, MD1, Maleen Cabe, MS1, Kelly Langert, PhD1 1Loyola University Chicago
9:30 AM. 235. Ionizable lipid nanoparticles for gene editing of the fetal lung.Adele Ricciardi, MD, PhD1, William Peranteau, MD2, Michael Mitchell, Ph.D.1 1University of Pennsylvania, 2Children's Hospital of Philadelphia
9:45 AM. 236. Targeting nanoparticle delivery to metastatic breast cancer by the intrathecal (cisterna magna) route.Chung-Fan Kuo, PhD1, Elena Andreyko, PhD1, Tobi Babayemi2, Kha Uyen Dam, BS1, Rachael Sirianni, PhD1 1UMass Chan Medical School, 2Rice University