5D: Biomaterials-Enhanced Cell Therapy: Beta Cells and Beyond
Time: 8:00 AM to 10:00 AM
Description
This symposium will highlight breakthroughs in biomaterials that enhance the feasibility and translational potential of cell therapies. Biomaterials have been developed to modulate cell behavior, protect cells from immune attacks, guide patient-specific cellular activity, and stimulate endogenous cell recruitment. One key focus area will be biomaterials that augment beta cell replacement for type 1 diabetes, but the session welcomes discussions on a wide range of cell therapy applications.
Moderators:
Edward Phelps, University of Florida
Jessica Weaver, Arizona State University
Objectives
8:30 AM. 207. Vasculogenic, Synthetic Hydrogel Enhances a Marginal Corrective Dose of SC-Islets in the Gonadal Fat Pad of Diabetic Immune Deficient Mice.Sophia Kioulaphides, M.S.1, Angelica Torres, B.S.1, Michael Hunckler, PhD1, Nathaniel Hogrebe, PhD2, Aayush Vaswani1, Graham Barber, B.S.1, Jeffrey Millman, PhD2, Esma Yolcu, PhD3, Haval Shirwan, PhD3, Andrés García1 1Georgia Institute of Technology, 2Washington University St. Louis, 3University of Missouri
8:45 AM. 208. Methacrylic acid-based hydrogel and tuned inflammatory response enable subcutaneous allogeneic islet survival.Sean Kinney, PhD1, Alexander Upenieks, MASc1, Michael Sefton, ScD1 1University of Toronto
9:00 AM. 209. Interrogating the Impact of Porous Scaffold Geometry on Host Responses and Transplant Outcomes In Vivo.Taylor Lansberry, BS1, Robert Accolla, PhD1, Cameron Crouse, BS1, Justin Walsh, BS1, Cherie Stabler, PhD1 1University of Florida
9:15 AM. 210. Anti-TNFα Antisense Oligonucleotide Conjugated PLG Nanoparticles Protect Transplanted Islets.Elizabeth Bealer, MS1, Namit Padgaonkar, BS1, Kelly Crumley, MS1, Eiji Saito, PhD1, Zoe Beekman1, Lonnie Shea1 1University of Michigan
9:30 AM. 211. Development and encapsulation of programable pro-angiogenic cell factories for long-term support of beta cell transplantation.ALVARO MORENO LOZANO1, Martha Fowler1, Shalini Pandey1, Jacob Cabler2, Cassidy Hart1, Michael Gill1, Samantha Fleury1, Yewen Wu3, Qixu Zhang3, Omid Veiseh1 1Rice University, 2Rice Univeristy, 3MD Anderson
9:45 AM. 212. In Vitro Model of the Confined Islet Transplant Site to Evaluate Direct and Indirect T Cell Cytotoxicity and Protective Effects of Islet Biomaterial Encapsulation.Ilaria Pasolini1, Grisell Gonzalez1, Alice Tomei1 1University of Miami