5C: Biomaterials for Organoids
Time: 8:00 AM to 10:00 AM
Description
Three-dimensional ex vivo organoid cultures using biomaterial-based assembly and self-assembly have been shown to resemble and recapitulate most of the functionality of diverse multicellular tissues and organs, such as the gut, brain, liver, kidney, and lung. They can be dissected and interrogated for fundamental mechanistic studies on human tissue development, regeneration and repair. They can also be used in diagnostics, disease modeling, drug discovery and personalized medicine. For example, in vitro disease models will provide cutting-edge approaches to replicate pathological conditions outside the human body. Thus, organoids bridge a gap in existing model systems by providing a more stable system that is amenable to extended cultivation and manipulation while being more representative of in vivo physiology. This session will cover the most recent advancements in biomaterials-mediated organoid and in vitro models of disease technologies in regenerative medicine, cancer therapy, drug testing, environmental control, monitoring, adaptive sensing, personalized medicine, therapeutic development and translational applications. This topic has been well-received in past SFB meetings and is an exciting emerging research area. In 2025, we will continue this session and promote translational research on the commercial viability of biomaterials-mediated organoid projects.
Moderators:
Qun Wang, Iowa State University
Janeta Zoldan, University of Texas
Objectives
8:00 AM. 198. Developing Chamber-Forming Human Cardiac Organoids in a Synthetic Hydrogel System.Zhen Ma1 1Syracuse University
8:15 AM. 199. Hypoimmunogenic hPSC-derived cardiac organoids evade the host immune response and facilitate cardiac functional recovery.Sophia Silver, BS1, Dimitrios Arhontoulis, PhD2, Nathaniel Hyams, BS1, Mei Li, MD2, Alessandro Howells, BS3, Ryan Barrs, PhD1, Jacelyn Bain, BS1, Charles Kerr, PhD1, Xiaojun Lian, PhD3, Leonardo Ferreira, PhD2, Ying Mei, PhD1 1Clemson University, 2Medical University of South Carolina, 3The Pennsylvania State University
8:30 AM. 200. MAGIC matrices: freeform bioprinting materials to support complex and reproducible organoid morphogenesis.Austin Graham, PhD1, Michelle Khoo, BS2, Vasudha Srivastava, PhD3, Kavita Parekh, BS4, Ophir Klein, MD, PhD3, Rafael Gómez-Sjöberg, PhD2, Zev Gartner, PhD3 1UCSF & CZBiohub, 2CZBiohub, 3UCSF, 4UC Berkeley
8:45 AM. 201. Enema Transplantation of Interleukin-10 Colonoids for the Treatment of Inflammatory Bowel Disease.Zahra Davoudi, Dr.1, Shadi Parvinroo, Dr.1, Dipak Sahoo, Dr.1, Albert Jergens, Dr.1, Michael Wannemuehler1, Qun Wang, Dr.1 1Iowa State University
9:00 AM. 202. Engineering Human iPSC Derived Planar Neural Organoid (PNO) Models to Study Melanoma Brain Metastases.Joydeb Majumder1, Elizabeth Torr2, William Murphy, PhD3, Apoorva Ramamurthy1, Ulrika Muller1 1University of Wisconsin-Madison, 2University of Wisconsin, 3University of Wisconsin Madison
9:15 AM. 203. FRESH 3D Bioprinting Cell Aggregates with Engineered Architectures.Samuel Moss, B.S.1, Brian Coffin, Ph.D.2, Daniel Shiwarski, Ph.D.2, Adam Feinberg, Ph.D.1 1Carnegie Mellon University, 2University of Pittsburgh
9:30 AM. 204. Innovating Brain Organoid Technology: Enhancing Lymphatic Vascularization with Synthetic Matrices.Dominique Gramm1, Donghyun Jeong1, Brenda Gonzalez1, Christopher Patzke1, Donny Hanjaya-Putra1 1University of Notre Dame
9:45 AM. 205. Optimizing Synthetic PEG-4MAL Hydrogels for the Culture of Patient-Derived Enteroids.Luis Arrieta-Viana1, Tatiana Karakasheva2, Katharine Hamilton3, Andrés García1 1Georgia Institute of Technology, 2Children's Hospital of Philadelphia, 3Children’s Hospital of Philadelphia