4D: Drug Delivery SIG 2

Date: Thursday, April 10, 2025
Time: 1:30 PM to 3:30 PM
Room: Marquette
Session Type: General Session

Description

This session will survey the diverse range of contemporary drug delivery systems and innovations. Drug delivering biomaterials can include nanoparticles, hydrogels, nanofibers, cell and virus-derived particles, or bioconjugates. Payloads can include DNA, RNA, antibodies, recombinant proteins, or small molecules. Disease applications can range from neurodegeneration to autoimmune disease, trauma, infection, or cancer. Work at all scales, from basic formulation science through therapeutic application in disease models is welcome. Studies that critically evaluate the impact of injection route on treatment efficacy and/or use novel imaging modalities to evaluate drug delivery performance are especially encouraged.

Moderators:

Gopal Agarwal, University of Florida
Lisa Volpatti, Northwestern University

Objectives

  • 1:30 PM. 158. Epigenetic-targeting nanotherapeutics for genetic kidney disease.Joshua Giblin, B.S.1, Eunji Chung, PhD1 1University of Southern California

  • 1:45 PM. 159. Controlled drug delivery with peptide hydrogel enabled with boronic acid dynamic covalent chemistry.Chaoyang Tang1, Brett Pogostin2, Samuel Wu1, Christopher Pennington1, Michael Swierczynski1, Dilrasbonu Vohidova1, Omid Veiseh1, Zachary Ball1, Jeffrey Hartgerink, Ph.D.1, Kevin McHugh, Ph.D.1 1Rice University, 2MIT

  • 2:00 PM. 160. Targeted Lipid Nanoparticle Delivery for Dual RNA-Mediated Treatment of Obesity.William Stewart1, Xiaoyang Xu1, Fengqiao Li2 1New Jersey Institute of Technology, 2New Jersey Institue of Technology

  • 2:15 PM. 161. Engineering CSF pH and tonicity for improved CNS nanoparticle and drug delivery.Constance Mietus, MD, PhD1, Olivia Mihalek2, Elena Andreyko, PhD2, Tobi Babayemi3, Rachael Sirianni, PhD2 1University of Massachusetts, 2UMass Chan Medical School, 3Rice University

  • 2:30 PM. 162. A Scalable, Translatable Hydrogel Platform for Improving Subunit Vaccines.Priya Ganesh1, Alexander Prossnitz, PhD1, Carolyn Jons, M.S.1, Ye Eun Song, M.S.1, Noah Eckman, M.S.1, Eric Appel, PhD1 1Stanford University

  • 2:45 PM. 163. Microneedle Patches for Minimally-Invasive Transdermal Nanoparticle Delivery.Haylee Wagner1, Tailynn McCarty1, Theo Prachyathipsakul1, Minelise Rivera De Jesus1, S. Thai Thayumanavan1, Cathal Kearney1 1University of Massachusetts Amherst

  • 3:00 PM. 164. Urease-Powered Nanomotor Containing STING Agonist for Bladder Cancer Immunotherapy.Sei Kwang Hahn1, Hyunsik Choi1 1POSTECH

  • 3:15 PM. 165. Enhancing Cell Transfection Efficiency via Modulation of Extracellular Fluid Viscosity.Yining Zhu1, Jingyao Ma1, Jiayuan Kong1, Di Yu1, Hai-Quan Mao1 1Johns Hopkins University