3G: Novel Biomaterial Developments in Non-Viral Drug Delivery Systems
Time: 8:00 AM to 10:00 AM
Description
Nucleic acid-based therapies or genetic medicines have the potential to treat a wide variety of conditions. Heavy reliance on viral methods, however, can hamper clinical translation and widespread use of such therapies. Non-viral approaches are required to avoid the risk of adverse immune reactions, enable redosing, and make nucleic acid-based therapies more affordable. This session will focus on showcasing biomaterials-based approaches to non-viral nucleic acid-based therapies. We encourage contributions spanning a wide range of biomaterials research applications, including the development of novel carrier systems (e.g., polymer- and lipid-based nanocarriers, engineered extracellular vesicles, physical methods, etc.), methods of deployment (e.g., controlled release, novel routes of administration, etc.), and therapeutic cargo (e.g., novel nucleic acid designs, aptamers, etc.), among others.
Moderators:
Daniel Galego-Perez, The Ohio State University
Qiabing Xu, Tufts University
Objectives
8:30 AM. 125. A Green Chemistry Approach to the Synthesis of Ionizable Lipids for Lipid Nanoparticle-Based mRNA Vaccines and Therapeutic Development.Xiaoyang Xu1, Zhongyu Li1 1New Jersey Institute of Technology
8:45 AM. 126. Engineering controlled release from biodegradable drug delivery devices 3D printed with vat polymerization.Hafiz Busari, M.S.1, O. Thompson Mefford, Ph.D.2, Michael Vaughn, Ph.D.3 1Pol-Med, Inc., 2Clemson University, 3Poly-Med, Inc.
9:00 AM. 127. Extracellular Vesicles Facilitate Motor-like Neuron Reprogramming to Support Temporary Muscle Reinnervation After Peripheral Nerve Injury.Ana Salazar Puerta, PhD1, Grant Barringer, Student1, Jon Stranan, MS1, Sara Kheirkhah, BS1, Hallie Harris, MS1, Megumi Fukuda, Student1, Amy Moore, MD1, Dave Arnold, MD2, Daniel Gallego-Perez, PhD1 1The Ohio State University, 2University of Missouri
9:15 AM. 128. Rapid, plate robot-integrated microfluidic generation and validation of large, precisely defined lipid nanoparticle libraries for screening.Andrew Hanna, BA1, Michael Mitchell, Ph.D.1, David Issadore, Ph.D1 1University of Pennsylvania
9:30 AM. 129. Multifunctional Nanoscale Delivery System for Breast Cancer Brain Metastasis.Metin Uz, Ph.D. in Chemical Engineering1, Mohd Ali Abbas Zaidi2, Asad Rehman2, Tugce Dogruel1, Laiba Anwar2, Mahek Fatima2, Md Arafat Khan Arafat Khan2, Parvez Khan3, juan Santamaria2, Mohd Wasim Nasser2 1Cleveland State University, 2University of Nebraska Medical Center, 3u
9:45 AM. 130. A Dendrimer-Based Ultrasound-Responsive Gene Delivery System for Precision Cancer Therapy.Nikita Sehgal, MS1, Kevin Schilling, PhD1, Riccardo Carloni, PhD1, Carolyn Schutt Ibsen, PhD1 1Oregon Health& Science University