3F: Drug Delivery SIG 1

Date: Thursday, April 10, 2025
Time: 8:00 AM to 10:00 AM
Room: Marquette
Session Type: General Session

Description

This session will survey the diverse range of contemporary drug delivery systems and innovations. Drug delivering biomaterials can include nanoparticles, hydrogels, nanofibers, cell and virus-derived particles, or bioconjugates. Payloads can include DNA, RNA, antibodies, recombinant proteins, or small molecules. Disease applications can range from neurodegeneration to autoimmune disease, trauma, infection, or cancer. Work at all scales, from basic formulation science through therapeutic application in disease models is welcome. Studies that critically evaluate the impact of injection route on treatment efficacy and/or use novel imaging modalities to evaluate drug delivery performance are especially encouraged.

Moderators:

Matt Webber, University of Notre Dame
Kevin McHugh, Rice University

Objectives

  • 8:00 AM. 116. Indoleamine 2,3-Dioxygenase Enzyme-Peptide Gel for Local Immune Modulation.Madeline Fuchs1, Jennifer Simonovich, MS1, Isabella Pinto1, Gregory Hudalla, PhD1, Benjamin Keselowsky, PhD1 1University of Florida

  • 8:15 AM. 117. A Regimen Compression Strategy Leveraging the Administration Route of an Injectable Hydrogel Depot Technology for Sustained Vaccine Exposure.Jerry Yan1, Leslee Nguyen2, Ibukun Ajifolokun3, Ben Ou, PhD2, Ye Eun Song, M.S.1, Eric Appel, PhD1 1Stanford University, 2Appel Group, Stanford University, 3Stanford

  • 8:30 AM. 118. Poly(beta-amino ester)/poly(lactic-co-glycolic acid) blends for co-delivery of small molecules and proteins to enable locoregional combination therapy of primary liver tumor.Hongzhe Yu1, Ling Li1, Florin Selaru1, Jordan Green, Ph.D.1 1Johns Hopkins University

  • 8:45 AM. 119. Glucose-Stabilized Peptide Assemblies for Glucagon Delivery.Matthew Webber, PhD1, Sihan Yu, PhD1, Weike Chen, PhD1 1University of Notre Dame

  • 9:00 AM. 120. Vaccine Delivery from a TLR7 Agonist-Functionalized Peptide Hydrogel Promotes Robust Humoral and Cellular Immune Responses.Kevin McHugh, Ph.D.1, Erin Euliano, Ph.D.1, Kevin McHugh, Ph.D.1, Kevin McHugh1, Kevin McHugh1, Kevin McHugh1, Tyler Graf1, Jeffrey Hartgerink, Ph.D.1 1Rice University

  • 9:15 AM. 121. Microgel-mediated delivery of decorin prevents pediatric vocal fold scarring.Ryan Friedman, Mr.1, Elizabeth Brown, Ms.1, Hannah Bonelli1, Matthew Aronson, Mr.1, Kendra McDaid, Dr.2, Riccardo Gottardi, Dovtort1 1University of Pennsylvania, 2Children's Hospital of Philadelphia

  • 9:30 AM. 122. Aromatic mRNA lipid nanoparticle platform confers vaccine protection with reduced off-target delivery.Hannah Yamagata, B.S.1, Marshall Padilla, PhD1, Michael Mitchell, Ph.D.1 1University of Pennsylvania

  • 9:45 AM. 123. Lipid nanoparticles targeting smooth muscle cells as a therapeutic platform for ACTA2 genetic vasculopathy of infancy.Eliz Amar Lewis1, Juan Carlos Oliva Estrada2, William Sawyer3, Sabyasachi Das4, Pazhanichamy Kalailingam4, Rashmi Richa4, Joseph Lawton4, Christiano Alves4, Lauren Fox4, Ben P. Kleinstiver4, Patricia Musolino4, Mark E Lindsay4, Natalie Artzi2 1Brigham and Women's Hospital, Haravard Medical School, 2Brigham and Women's Hospital, Harvard Medical School, 3Brigham and Women’s Hospital, Harvard Medical School, 4Massachusetts General Hospital