2E: Engineering Heart and Lung Models to Study Disease Progression and Therapeutic Development
Time: 2:45 PM to 4:15 PM
Description
This session focuses on leveraging biomaterials to create models of the heart and lung, including engineered tissues, organoid, and/or organs-on-a-chip, and how these systems can be leveraged to understand disease processes and as a testbed to identify and test potential therapeutics. These models can be used to develop treatments for acute conditions such as virus infections, to investigate mechanisms of chronic disease progression, for toxicology testing, and overcome the limitations of animal models used for cardio-pulmonary research. Approaches that combine in vitro models with state-of-the-art techniques for phenotyping, including bulk and spatially resolved omics technologies and cutting-edge data analysis and visualization such as machine learning are also encouraged
Moderator:
Claudia Loebel, University of Michigan
Objectives
2:45 PM. 61. Development of an engineered heart tissue platform to study the progressive tissue stiffness change in hypertrophic cardiomyopathy.Ganesh Malayath1, Huanzhu Jiang1, Ghiska Ramahdita1, Yasaman Kargar Gaz Kooh1, Nathaniel Huebsch, PhD1 1Washington University in St. Louis
3:00 PM. 62. Modeling Cardiomyocyte-fibroblast Crosstalk in Hypertrophic Cardiomyopathy Pathogenesis using iPSC-derived Micro Heart Tissue.Huanzhu Jiang1, Ganesh Malayath1, Ghiska Ramahdita1, Yasaman Kargar Gaz Kooh1, Sharon Cresci1, Nathaniel Huebsch, PhD1 1Washington University in St. Louis
3:15 PM. 63. High Throughput Fabrication of Human Engineered Heart Tissues for Modeling of Pathological Cardiac Hypertrophy.Abhishek Dhand1, Miranda Juarros2, Thomas Martin2, Leslie Leinwand2, Jason Burdick2 1University of Pennsylvania, 2University of Colorado, Boulder
3:30 PM. 64. Multilayered Cardiac Microtissues for Dissecting Homeostatic vs. Fibrotic Intercellular Communication.Emmanouil Agrafiotis, PhD1, Samuel DePalma, PhD2, Darcy D. Huang3, Anya G. Coffeen Vandeven1, Austin E. Stis4, Jingyi Xia1, Brendon Baker, Ph.D.1 1University of Michigan, 2Broad Institute, 3University of P, 4University of Florida
3:45 PM. 65. Epithelial Cell-Specific Nascent Matrix Deposition Directs Cell Differentiation within the Lung.Donia Ahmed1, Matthew Tan, Ph.D.1, Jingyi Xia1, Brendon Baker, Ph.D.1, Claudia Loebel, M.D., Ph.D.1 1University of Michigan
4:00 PM. 66. Heightened matrix fiber density drives aberrant angiogenesis to propagate fibrotic signaling.William Wang, PhD1, Jingyi Xia1, Kyle Jacobs, MS2, Ariella Shikanov, Ph.D.1, Matthew Kutys, PhD2, Brendon Baker, Ph.D.1 1University of Michigan, 2UCSF