2B: Biomaterial-Mediated Immune Modulation for Autoimmunity Treatment

Date: Wednesday, April 9, 2025
Time: 2:45 PM to 4:15 PM
Room: 4D
Session Type: General Session

Description

Autoimmune diseases, including multiple sclerosis and rheumatoid arthritis, affect over 24 million Americans and are among the leading causes of disability and death in the United States, disproportionately impacting women. A broad spectrum of biomaterials has been engineered to address autoimmunity by modulating immune responses via several mechanisms, such as delivering immunosuppressive drugs, inducing anti-inflammatory reactions, and enhancing regulatory immune cell functions. The proposed session aims to showcase recent studies that utilize biomaterial design to foster tolerogenic responses in the treatment of autoimmune and inflammatory conditions.

Moderators:

Yaoying Wu, Syracuse University
Era Jain, Syracuse University

Objectives

  • 2:45 PM. 43. Injectable hydrogels for localized induction of regulatory T cells. Kenneth Kim, MS1, Lindsay Hager2, Arielle D'Elia, MS2, Christopher Rodell, Ph.D.2 1Drexel University College of Medicine, 2Drexel University

  • 3:00 PM. 44. Localized versus Systemically Delivered Immunomodulation for Treatment of Psoriasis. Jennifer Simonovich, MS1, Sabrina Macias, PhD1, Arun Wanchoo, PhD1, Dorina Avram, PhD2, Gregory Hudalla, PhD1, Benjamin Keselowsky, PhD1 1University of Florida, 2Moffitt Cancer Center

  • 3:15 PM. 45. Antigen-Conjugated Scaffolds for Enrichment of Disease-Specific T-cells. Sydney Wheeler, MSE1, Mary Dickenson, MSE1, Samantha Lukpat, BSE1, Leon Wagner, MSE1, Aaron Morris, PhD1 1University of Michigan

  • 3:30 PM. 46. Iron-Dexamethasone Nanoparticles Prevent Neutrophil Activation in Acute Lung Injury. Michael Felder1, Valentina Guevara1, Daniel Kupor1, Lola Eniola-Adefeso2 1University of Michigan, 2University of Chicago, Illinois

  • 3:45 PM. 47. Macroporous Gelatin Scaffolds Enable Lymph Node Stromal Cell Delivery for T-cell Immunomodulation and Recirculation in Type 1 Diabetes Mouse Models. Leonor Teles, BS1, Zachary Wilkes, BS1, Ana Hernandez, BS1, Logan Beatty, BS1, Camillo Bechi Genzano, MD2, Remi Creusot, PhD2, Alice Tomei, PhD1 1University of Miami, 2Columbia University

  • 4:00 PM. 48. Microneedle Targeting of the Immunological Niche in Skin to Induce Antigen-Specific Immune Tolerance and Counter Autoimmunity.Robert Oakes, PhD1, Shrey Shah, MS2, Camilla Edwards2, Senta Kapnick, PhD2, Christopher Jewell, PhD2 1University of Delaware, 2University of Maryland