1F: Microfluidics and Biomaterials for Engineering 3D In Vitro Models
Time: 1:00 PM to 2:30 PM
Description
This session aims to explore the cutting-edge intersection of microfluidic technologies and biomaterials in the development of advanced three-dimensional (3D) in vitro models. As traditional 2D cultures fail to accurately mimic the complexity of tissues, organs, and their in vivo microenvironment, this session will explore how emerging techniques including microfluidics and organoids can be integrated with biomaterials to recreate the dynamic physiological conditions essential for accurate disease modeling, drug testing, and overall phenomena understanding. Topics will include innovations in 3D biomaterial design, the role of microfluidics in both manipulating materials for biofabrication as well as interconnecting complex on-chip cellular microenvironments, organoids, and the application of these systems in tissue engineering, cancer research, and organ-on-chip platforms. A discussion on the challenges and future directions in scaling these models for high-throughput screening and personalized medicine is to be expected.
Moderators:
Carlos Ferreira Guimaraes, University of Minho
Objectives
1:30 PM. 26. High-throughput buoyancy-driven microgel production for simple user interfacing. Durante Pioche-Lee1, Xiaoqian Wang1, Yoke Qi Ho1, Wahidur Rahman1, Armen Vartanian1, Sasha Cai Lesher-Pérez2 1University of Michigan, 2Univeristy of Michigan
1:45 PM. 27. Microfluidic Hydrogel Biofabrication of Miniaturized 3D Cellular Architectures for Cancer Modeling. Carlos Guimarães1, Luca Gasperini1, Ramón Silva1, Rui Reis1 1University of Minho
2:00 PM. 28. Engineered curvature directs matrix deposition during jamming and unjamming transitions. Avinava Roy, M.S.E1, Katherine Wei, B.S1, Max Shtein, Ph.D1, Claudia Loebel, M.D., Ph.D.1 1University of Michigan
2:15 PM. 29. Myofibroblast De-differentiation and Fibrotic Tissue Reversion in a Synthetic 3D Interstitial Matrix. Jingyi Xia1, arjun Gupta1, Ethan poupard1, Vincent Fiore, PhD2, Brendon Baker, Ph.D.1, Daniel Matera3 1University of michigan, 2Boehringer Ingelheim, 3Draper