1E: Immune Biomechanics & Mechanobiology
Time: 1:00 PM to 2:30 PM
Description
Evidence is emerging that the immune cells respond to the mechanical properties of their microenvironment and this can modulate their function and activation. This session will focus on immune cell interactions with biomaterials and tissues in the context of biomechanics, how this is used to modulate immune function, and how this affects immune tissue models we build.
Moderators:
Bethany Almeida, Clarkson University
Objectives
1:00 PM. 19. Engineering Immunomodulatory Biomaterials for Modulating Macrophage-Mediated Fibrosis in Fracture Nonunion. Matthew Patrick, BS1, Ramkumar Annamalai1 1University at Buffalo
1:15 PM. 20. Piezo1 Mediates Shear-Stress-Induced Signal Two in NLRP3 Inflammasome Activation. Adam Fish1, James Forster1, Vaishali Malik1, Ashish Kulkarni1 1University of Massachusetts Amherst
1:30 PM. 21. Mechanical forces at Immune Synapse Regulate Therapeutic Response in Diffuse Large B Cell Lymphoma. Deepali Balasubramani1, Stefano Travaglino1, Hyun-Kyu Choi, PhD1, Cheng Zhu, PhD1, Ankur Singh, PhD1 1Georgia Institute of Technology
1:45 PM. 22. Studying and Targeting Macrophage Mechanics on Earth and in Space. Meenal Datta, PhD1, Alice Burchett, B.S.1 1University of Notre Dame
2:00 PM. 23. Extracellular matrix damage modulates inflammatory response in fibroblasts through mechanotransductive pathways. Alisa Isaac, PhD1, Teja Guda2, Ope Sanyaolu1, Victoria Garza1 1UTSA, 2The University of Texas at San Antonio
2:15 PM. 24. Sliding hydrogels reveal that modulation of mechanosensing attenuates the inflammatory phenotype of osteoarthritic chondrocytes in 3D. Manish Ayushman1, Hung-Pang Lee, Ph.D.2, Pranay Agarwal, Ph.D.2, Georgios Mikos2, Xinming Tong, Ph.D.1, Sarah Jones1, Sauradeep Sinha, Ph.D.1, Stuart Goodman, MD/PhD1, Nidhi Bhutani, Ph.D.1, Fan Yang, Ph.D.1 1Stanford University, 2Stanford